Comment · Fri, November 21, 2014 · Ceretropic
N-ACETYL SEMAX SOLUTION
Original post in this thread
[deleted] · 5 points
So I just ordered my first vial of the newly formulated semax.
Based on the description it is supposed to be stronger and more effective than the previous version. I am currently using the previous version with my son.
Has anyone used this product yet and what dosage have you tried?
I am going to be trying 300mcg via injection. i am currently taking 1mg daily of the old mix but if this thing as good as it is described maybe I won't need the same dosage.
What they were answering
relbatnrut · 2 points
I can't believe I'm playing the devil's advocate for amphetamine, but haven't most in vivo studies pointed to little to no long term harm with chronic low doses (and possibly benefits)? And haven't in vivo studies on n-acetyl-semax pointed to...well, nothing? Because there haven't been any?
I don't know, I trust that you're right, but it's still only theory.
u/MisterYouAreSoDumb · Ceretropic
Semax has many studies behind it. The Acetyl group is not going to change the affinities, just the bioavailability and stability. So that begs the question: is Semax safer than amphetamine?
Amphetamine is relatively safe when used in low dosages. However, there are many people that report long term changes from even low therapeutic dosages long term. But just the fact that amphetamine can be neurotoxic, makes it less safe than Semax.
http://jpet.aspetjournals.org/content/286/2/1074.short
That study used 3mg/kg in rats, which is .48mg/kg in humans. That is a 39mg dose for my body weight, which is still in the therapeutic levels.
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This study demonstrates that administration of low doses of amphetamine or methylphenidate differentially traffic VMAT-2 within nerve terminals, with effects similar to those observed after high-dose administration.
So even low dosages can redistribute VMAT-2
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Literature Review: Update on Amphetamine Neurotoxicity and Its Relevance to the Treatment of ADHD
In early studies, high doses of amphetamine, comparable to amounts used by addicts, were shown to damage dopaminergic pathways. More recent studies, using therapeutic regimens, appear contradictory. One paradigm shows significant decreases in striatal dopamine and transporter density after oral administration of “therapeutic” doses in primates. Another shows morphological evidence of “trophic” dendritic growth in the brains of adult and juvenile rats given systemic injections mimicking “therapeutic” treatment.
So no harm in playing devils advocate. We cannot say for certain one way or the other. However, I would definitely be more comfortable giving my child N-Acetyl Semax, or regular Semax, before I would give him amphetamine.