Comment · Sat, August 9, 2014
Weird experience with MDMA and 5-HTP
Original post in this thread
emprise · 13 points
Hey good fellas.
I have taken around 250~300mg of clean ecstasy pills last night.
00:00 - took 200mg
01:30 - redosed with 50~100mg
04:30 - coming down, took a 5HTP pill.
05:00 - tingling sensations arising all of a sudden around my whole body, starting with hands and spreading from there.
05:15 - suddenly feeling like I'm rolling again, but with weird side effects such as my hands and feet not getting enough blood.
06:30 - effects die out.
Sources advise people to take 5htp when coming down. I have been not informed of side effects. I'm looking for some enlightenment.
What happened?
edit: Appreciate the informative answers here. I will have to research more on this 'serotonin syndrome.' Rest assured that the same mistake will not happen again and, on goodwill, that I will spread this information with others.
What they were answering
PunishableOffence · 5 points
5-htp should have no direct effect on your sensation when taken during a roll
Bullshit. 5-HTP can and will metabolize into serotonin in the periphery, causing vasoconstriction.
This is why you take the parent precursor L-tryptophan and not 5-HTP.
u/MisterYouAreSoDumb
There's no point in taking L-trypophan after MDMA, since your tryptophan hydroxylase enzyme will be down-regulated. But you need to take EGCG with the 5-HTP, to inhibit peripheral aromatic L-amino acid decarboxylase. That will prevent it from converting to 5-HT before passing the BBB. But you should always wait till your MDMA plasma levels are low before dosing the 5-HTP. Most people should just wait till the next day.