Comment · Thu, July 31, 2014 · Ceretropic
Administration of low dose methamphetamine 12 h after a severe traumatic brain injury prevents neurological dysfunction and cognitive impairment in rats (2013)
What they were answering
FW900 · 5 points
I believe you are mistaken. D-METH has a higher affinity for DA, making it more dopamine heavy?
Lower value = higher affinity
NE DA 5-HT
(d)-Methamphetamine 489 24. 736
(d)-Amphetamine 7.1 110.3 1,765
http://en.wikipedia.org/wiki/Dopamine_releasing_agent
EDIT: Unless by D-amp, you meant D-methamp ?
u/MisterYouAreSoDumb · Ceretropic
No, I mean it is more tipped toward dopamine than balanced out with serotonin. The SERT affinities of D-meth balance out the dopamine release. This makes it a lot smoother than D-amp, which is dopamine heavy. Remember, we are talking about microdosing it. Obviously taking a large dose of meth is going to be too much of both dopamine and serotonin. But the balance that meth has over D-amp is what we are looking for.
I suppose my wording was unclear. Just look at the NE and DA balance of D-amp, and compare it to the more balance (in effects) release that meth has. Meth is smoother, and less of a specific DA/NE dump, with no balance in 5-HT. The NE plays a huge role in this too.