Comment · Sun, July 13, 2014
Other Possible MDMA/Ecstasy Supplements?
Original post in this thread
[deleted] · 7 points
There is an excellent MDMA Supplementation list here:
http://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/
And I notice there are some anti-oxidant supplements listed.
Most of them dont score very high on ORAC value charts. (ORAC is an abbreviation for Oxygen Radical Absorbance Capacity... basically measures antioxidant capacities). Should we be supplementing with foods like cinnamon, cloves, turmeric and cocoa powder instead of Vitamin C, grapefruit juice, etc?
On the Supplementation list linked above there are also a few supplements meant to help with the increase in depleted serotonin levels (such as 5-HTP). Would it be wise to also include SAMe, L-tryptophan, and St. John's wort to help serotonin levels?
Thanks for any input!
What they were answering
baronjpetor · 1 points
OK well noted. But isn't ALA a glutathione precursor too ?
What about the other serotoninergic compounds (4-FA, M1, benzofurans and whatever I'm forgetting) that supposedly don't produce the same toxic metabolites as MDMA ? Would glutatione have any unwanted interaction with their own metabolites too ?
u/MisterYouAreSoDumb
ALA can boost glutathione levels, but in a different way than NAC. Also, ALA has been proven to prevent MDMA induced neurotoxicity, so that is why it is my go-to antioxidant. NAC could very well be beneficial too. I just need some more data to be comfortable with it.
Also, if you take NAC after alcohol, it causes more damage. I do not want to have a paradoxical reaction like that with MDMA.
The other compounds do not lead to the same metabolites as MDMA, so there should not be the same interaction. However, a lot of those substances do not have a lot of data on them. There might be something we are missing regarding their pharmacodynamics.