Comment · Wed, February 19, 2014 · Ceretropic
Piracetam stopped working
Original post in this thread
[deleted] · 8 points
Hi r/nootropics,
About half a year ago I tried Piracetam for the first time. After a few days taking about 2g daily I started to notice really pleasant effects. The main thing was that talking to friends or colleagues was sooo much easier and better. I came up with the perfect word combinations in milliseconds. Before this was definitely a problem for me. Sometimes and especially in situations where I didn't feel perfectly comfortable in I often had trouble coming up with words. That was all gone at that point. I don't know if this was due to reduced anxiety/increased self-esteem or if piracetam really made a difference in how my brain functioned. I didn't really care, because what was important for me was that it worked! That lasted for about two weeks and after that the effects became more and more rare until they disappeared completely.
I know this sounds a lot like placebo but I'm pretty convicend that it's not. I ordered piracetam in the first place to help me at work/university and to improve memory and cognition. I didn't even know that it can help with social skills/anxiety whatever you want to call it. I found out about that later. Also those improvements were so profou…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
I really do think there is some mechanism surrounding the NMDA receptors that is causing tolerance. Tolerance to many things, like opiates and amphetamines, are mediated by the NMDA receptors. So positively modulating them, a la piracetam, might lead to tolerance as well.
After starting memantine, my tolerance to many things reset. This includes racetams. I think there is a balance that needs to be had with calcium transmission through one's NMDA receptors, and any positive modulation is going to lead to some level of tolerance.