Comment · Fri, September 27, 2013
The LSD Micro-dosing experiment
Original post in this thread
tossed_hither · 482 points
In the article here: http://www.themorningnews.org/article/the-heretic Dr. Fadiman talks about micro-dosing with LSD. This piqued my interest and I decided to give it a try. I happened to have some LSD laying around.
I decided to try a 10 micro-gram dose per day for 15 days, at which point I will stop.
In order to measure out 10ug, I took one 150ug blotter, placed it into a chlorine free 20oz bottle of water and shook violently. I then used a measuring tape to mark off 15 equal sections of water. This is not precise, but has worked well thus far. I let the Blotter sit in the bottle overnight, and then shook violently again the following morning before my first dose. The last time I ingested LSD before this experience was about 60 days ago.
What follows are my logs over the first 48 hours and change, I will continue to log for the next 13 days.
9/25/13
638a 10ug taken
735a traffic was bad. Want to think I feel something. Maybe tricking myself
800a ok so I definitely feel some elation, and feeling quite social
946a energy levels are much higher than usual, warm feeling all over, texture and color seem more apparent. spent some time staring intently at a wall to deter…
What they were answering
Etheri · 2 points
And mescaline is the only one, and an exception at almost all times. 'Most'.
Shrooms, dmt, lsd, they're mostly gone before you're even done tripping.
u/MisterYouAreSoDumb
That is not true, though. The assertion that LSD's half life was shorter than it's peak effects has been disproven. Plasma half life of LSD is roughly 5 hours. It takes almost a day to completely eliminate it from the body.
http://www.ncbi.nlm.nih.gov/pubmed/2374410
The apparent plasma half-life was determined to be 5.1 h. The peak plasma concentration of 1.9 ng/mL occurred 3 h after administration
4-HO-DMT has an average half life of 3 hours.
http://www.maps.org/research/psilo/psilo_ib.pdf
Psilocin half-life ranges between 2 and 3 hours, and is detectable 6 hours after oral administration
DMT has a 15 minute half life, and much shorter effects. That is, unless taken with MAOIs like done with ayahuasca. But then the effects are much longer too.
http://jat.oxfordjournals.org/content/20/6/492.short
http://archpsyc.jamanetwork.com/article.aspx?articleid=496497
All of the pharmacodynamic data is in line with their effect profiles. Plasma concentration has a linear relationship with effects. Were you just trying to state that tryptamines generally have shorter half lives than psychedelic phenylethylamines?