Comment · Fri, September 27, 2013
The LSD Micro-dosing experiment
Original post in this thread
tossed_hither · 482 points
In the article here: http://www.themorningnews.org/article/the-heretic Dr. Fadiman talks about micro-dosing with LSD. This piqued my interest and I decided to give it a try. I happened to have some LSD laying around.
I decided to try a 10 micro-gram dose per day for 15 days, at which point I will stop.
In order to measure out 10ug, I took one 150ug blotter, placed it into a chlorine free 20oz bottle of water and shook violently. I then used a measuring tape to mark off 15 equal sections of water. This is not precise, but has worked well thus far. I let the Blotter sit in the bottle overnight, and then shook violently again the following morning before my first dose. The last time I ingested LSD before this experience was about 60 days ago.
What follows are my logs over the first 48 hours and change, I will continue to log for the next 13 days.
9/25/13
638a 10ug taken
735a traffic was bad. Want to think I feel something. Maybe tricking myself
800a ok so I definitely feel some elation, and feeling quite social
946a energy levels are much higher than usual, warm feeling all over, texture and color seem more apparent. spent some time staring intently at a wall to deter…
What they were answering
Etheri · 3 points
http://www.erowid.org/chemicals/lsd/lsd_myth1.shtml
Your study is in there, it also seems to be by far the longest among all the other sources, other sources going as low as two and a half hour. It may be a more recent study, but ...
In a single volunteer given about 70 ug, the apparent plasma half-life of LSD is 5.1 hr. The peak plasma concentration of 1.9 ng/mL occurred 3 hr after administration.
One volunteer, fairly low dose. Not suprising times go up as the concentration goes down.
Psilocybin? I expect to be peaking 2 to 3 hours after I eat them, considering it takes a while to even get the effects.
Either way, none of this was my point. My point was that LSD won't actually stack up in your body on daily use, something that cannot be said about plenty of other drugs and may make them less suitable for daily microdosing. I don't even want to know howmuch THC stacks up in my body fat, probably enough to get people with lower tolerances high if I could extract it ;).
u/MisterYouAreSoDumb
Ohh sure, at these doses there will be no accumulation like what would happen with vitamin D or another fat soluble molecule. THC definitely accumulates a lot!
Keep in mind most people eat shrooms to get their psilocin. That takes longer, due to the conversion from psilocybin. If you take pure 4-HO-DMT, it will hit faster. So the pharmacodynamics of shrooms is much more complicated than pure psilocin. That is why the lemon tek is popular for stronger and faster effects.