Comment · Tue, August 13, 2013 · Ceretropic
Memantine + Aniracetam have negated mechanisms of action. What happens when you take them?
Original post in this thread
willonz · 12 points
Enlighten me with your wisdom with this combination.
Have any of you gentlefolk intentionally tried this combination? What dosage at each substance?
I recently ordered some n=30 10 mg Memantine HCL and it just arrived in the mail today. I take .666 g of Aniracetam plus 500mg of Choline & Inositol daily.
To be specific, I would like to start taking Memantine HCL but have slight hesitance, because Memantine is a low-affinity voltage-dependent uncompetitive antagonist at the NMDA receptor; while Aniracetam and nootropic racetams in general are positive allosteric modulators at AMPA receptors. The specific mechanism of action per receptor protein is not specific, keeping in mind the conjoined effect of AMPAfication has on NMDA receptor availability, might have some correlation, thus hypothetically generating an asynergistic ('negated' in title) mechanism of action.
My hypothesis is that with an added low Ki antagonist to NMDA, would either downregulate AMPA or have no effect on such regulation, then any significant depolarization of NMDA would have a lesser effect on Aniracetam's positive excitetory modulation on NMDA, inducing a generally negated response between the two drugs.…
What they were answering
willonz · 3 points
Great response. Thanks! Your logic is undeniable.
I'm not concerned about any toxic synergism, as the doses are low.
I took 30 mg about an hour ago and I feel just more relaxed, maybe even a little euphoric. So far so good.
u/MisterYouAreSoDumb · Ceretropic
Most people report slight euphoria the first week of mematine usage. Since tolerance to euphoria is NMDA receptor mediated, I'm sure there is some underlying mechanism we don't fully understand yet.
Report back if you feel any brain fog, or cloudiness. That is a common side effect week one, and I am curious if the aniracetam will counteract it. I have a feeling it will.