Man 'took 40,000 ecstasy tablets' - Doctors have revealed details of the biggest recorded user of ecstasy - a man estimated to have taken 40,000 ecstasy pills in his life.

Comment · Mon, April 8, 2013 · 44 pts

The metabolism characteristics of the drug mean that the first dose inhibits the main metabolic pathway, CYP2D6. This means that any subsequent doses are more likely to use the secondary metabolic pathway, CYP3A4. The CY

Comment · Mon, April 8, 2013 · 2 pts

http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/ http://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/ I know ;-)

Comment · Tue, April 9, 2013 · 5 pts

No, in one night. The enzyme inhibition last for 24-48hrs. Not that I am saying it's good to take it again after 48hrs either. The rule is no re-dosing 1.5 hours after your first dose. Then wait 1 month to take it again

Comment · Tue, April 9, 2013 · 4 pts

Very little as long as you keep your body temperatures down. Take a look at my supplementation post. That should mitigate almost all of the toxicity, neurological or peripheral. http://www.reddit.com/r/DrugNerds/comment

Comment · Tue, April 9, 2013 · 2 pts

Yeah, re-dosing and body temperature can bring that level up to significant amounts. Since it's almost 100% correlated with 5-HT system damage, that is where my MDA theory came into light. I am 99% sure that MDA is the m

Comment · Thu, April 11, 2013 · 1 pts

If you want MDA like visuals, then 6-APB is for you. You just need to supplement for the vasoconstriction, or it gets uncomfortable. I'd suggest large doses of taurine, l-arginine, and possibly some THC. Since the benzof