Comment · Wed, March 13, 2013

Irreversible tolerances.

Original post in this thread

StiffyAllDay · 31 points

Hello all,

Just wanted to ask you if any of you have some good papers or articles on 'Irreversible tolerances' of some drugs. It has been said that 25x-nbomes could produce this, and also the loss of magic with MDMA, but I've struggled to find some good info on it.

Any reading on this will be great, cheers.

What they were answering

Flamewall26 · 3 points

Fun fact of the day: opiates and amphetamine tolerance occurs via the same mechanism of action

u/MisterYouAreSoDumb

Correct, the NMDA receptors. Magnesium supplementation helps a lot. Or you could go all out and get memantine. It has to do with extracellular glutamate. That is your body's primary excitatory neurotransmitter. It's involved heavily in euphoria.

EDIT: God damn do I hate it when people downvote accurate info. Fuck you too, moron!

Here are some studies regarding NMDARs and tolerance to various substances:

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/31836/0000783.pdf;jsessionid=47CDD5806617B39DBF5C00F2DA1B6031?sequence=1

http://www.ncbi.nlm.nih.gov/pubmed/11915303

http://www.ncbi.nlm.nih.gov/pubmed/9560846

http://www.sciencedirect.com/science/article/pii/S016501739900020X

http://www.ncbi.nlm.nih.gov/pubmed/2671566

http://www.jneurosci.org/content/16/13/4231.short

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615322/

http://www.ncbi.nlm.nih.gov/pubmed/15153783

http://www.ncbi.nlm.nih.gov/pubmed/16790637

http://www.ncbi.nlm.nih.gov/pubmed/1831064

http://www.ncbi.nlm.nih.gov/pubmed/1596749

http://www.ncbi.nlm.nih.gov/pubmed/17994223

http://www.ncbi.nlm.nih.gov/pubmed/19806811

http://www.ncbi.nlm.nih.gov/pubmed/9187317

http://www.ncbi.nlm.nih.gov/pubmed/1382178

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