Comment · Sat, March 9, 2013
Help, psychedelics stopped working for me after 25-x NBOME.
Original post in this thread
t3hv1ru5 · 25 points
I've tripped a few times - a few shroom trips, and acid once.
A few months ago I took 2 tabs of an NBOME compound and didn't trip at all, experiencing a uncomfortable comeup and "immunity" to weed, as in trying to smoke copious amounts in order to launch the trip produced zero effects. My friends had tripped on the same tabs before. I thought that it would be no big deal, that I just hasn't taken enough.
My last psychedelic experience prior to this was 1.5g shrooms, well over a month before.
However, one month later I took two tabs of acid, and had the exact same thing: an uncomfortable comeup an inability to get high from weed. My friends tripped moderately. I didn't know what was going on.
A month again after that, I took 4g shrooms and experienced THE SAME THING again. No trip, a couple hours of body lightness and anxiety, then nothing. A friend took 3g of the same shrooms and tripped balls.
Two months later, I took three tabs of acid and once again did not trip, whereas my friend tripped intensely. I actually got visual distortions this time, which lasted for around 15 minutes. I ate a 100mg THC edible two hours in, which should have completely floored me. I felt more s…
What they were answering
AtomikPi · 3 points
It's my understanding that glycine is a coagonist of the NMDA site. (IE the receptor needs both NMDA and glycine to fire. And that's why something like schizophrenia, which seems to have an NMDA hypofunction component, has been experimentally treated with glycine site agonists and reuptake inhibitors.) So it would actually likely do the reverse of what we want.
u/MisterYouAreSoDumb
Glycine is merely a transport amino acid for the magnesium to be chelated to, so that it increases bioavailability. It is a weak co-agonist of the NMDA receptor, along side glutamate. However, without glutamate present, the NMDA channel will not open. That, and the fact that the magnesium molecule it just helped cross the BBB is going to block the channel until in reaches excitability, means that the glycine will not hinder the effects we are looking for. In fact, glycine is an inhibitory neurotransmitter when it binds to it's own non-NMDA receptors, by allowing chloride to enter the cells. Magnesium glycinate is my go to form of Mg!