Comment · Thu, January 31, 2013 · Ceretropic
α-Lipoic Acid Induced Elevated S-adenosylhomocysteine and Depleted S-adenosylmethionine
What they were answering
Nicker · 2 points
Aside from this subreddit turning into a place where people just post links to ncbi.nlm.nih.gov with no reference to what they think, or even if they understand what they're linking (karma whoring some might call it).
I wish we could enact a rule in this subreddit that you cannot just post links without a proper discussion, as relying on others will just create it leads more to a void/dead area growing in the subreddit.
With that little preamble, here's what I gathered:
We have Na-R-ALA available to us, and if you want to take ALA, I suggest that.
>
> R-(+)-LA has significantly higher bioavailability and thus, might be expected to have more effect on methylation status
> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782850/#R38
Since
Commonly used doses of LA in human disease range from 600-1800 mg/day (1), which for a 70 kg person will range from roughly 9->26 mg/kg, thus 4-10-fold less than in our rat model.
So you can get higher bioavailability using the R-ala
then again, you can read more about this article here: http://www.longecity.org/forum/topic/33467-alpha-lipoic-acid-causes-massive-s-adenosylmethionine-sam-depletion/
As the article is now 3&1/2 years old... I request people stop posting old studies without adding anything of a positive reference/value... I reiterate, links are just being posted for Karma without any beneficial thoughts/analysis.
u/MisterYouAreSoDumb · Ceretropic
I would agree, and I did discuss that with the other moderators a couple weeks ago. I will bring it back up with them, as I am in agreement with you. I would rather have self posts that started discussions on the subjects, rather than a ton of links. I equated it to turning us into a search result for Google Scholar. We need to try and foster more in-depth discussions and forget about fake internet points. I refuse to make anything but self posts because of this.