Comment · Sat, December 29, 2012
Neural and cardiac toxicities associated with MDMA: Reversal of MDMA-Induced 5-HT Depletion by l-5-Hydroxytryptophan
What they were answering
tstu · 2 points
From the article: "MDMA produces pharmacological actions at the same doses in rats and humans (e.g., 1–2 mg/kg), which argues against the arbitrary use of allometric scaling to adjust doses between these species." Spinbox's analogy might have some merit as to the dosage comparison if I understand this correctly
u/MisterYouAreSoDumb
They are arguing that since they saw effects in the mice at 1-2mg/kg, and humans also show effects at that dosage, that the normal rules for allometric scaling may not apply with MDMA. I do not feel that their postulation has enough evidence behind it at this point. Primates show 5-HT system damage at 1.5mg/kg, where this study showed no 5-HT system damage at that dosage in rats. How can they explain the inconsistencies with all the other studies out there? There has to be some allometric scaling between the species. In any event, my comment was more to explain why they were injecting the rats with seemingly outrageous dosages.