Comment · Sat, December 22, 2012
Please help me understand binding affinities
Original post in this thread
kbrc · 13 points
I re-read the ACMD report on MXE just now and saw that it shows binding affinity for SERT (serotonin transporter), but no serotonin receptors (e.g. 5-HT2A like many psychedelics). Could someone explain simply what this means? My understanding is that SERT is sort of the "cargo vessel" for serotonin that docks with serotonin receptors to onload or offload serotonin "cargo". So if MXE binds to SERT, does this mean it's imitation "cargo" and eventually gets offloaded non-selectively to all serotonin receptors? Or that the real serotonin "cargo" gets left on the receptor "docks" (or the synaptic "sea") for longer because the transporters are busy handling MXE? Or perhaps my analogy just totally silly and I need a new understanding entirely.
I'd like to understand the general mechanism here, and also would like to know specifically if MXE would be cross-tolerant with psychedelics that bind to 5-HTx receptors.
What they were answering
kbrc · 1 points
I haven't seen that, although it gives me some pause. Where have you been seeing reports of that?
u/MisterYouAreSoDumb
I saw it on bluelight.
http://www.bluelight.ru/vb/threads/563915-suspected-serotonin-syndrome-from-methoxetamine-use
Here is one on drugs-forum that talks about combining it with Tramadol and causing serotonin syndrome.