Comment · Sun, November 4, 2012
do you think ecstasy users underestimate the dangers of the drug (particularly hyperthermia-related issues)?
Original post in this thread
pylori · 14 points
if you're aware of the issues it's not too hard to remain safe whilst using it, but the fact that so many people are uninformed about the dangers/risks makes things worse (death from ecstasy is reported to be in the 1 in 2000 range). also the fact that the quality/purity of the drug is so varied probably doesn't help things either (as well as being cut with other substances.
i read one case report of a police confiscated pill containing 270mg! jeez imagine taking that amount for the first time, and one patient presented with a temperature of 43C!
i think there's more rave organisers could do to ensure people remain hydrated, and, more importantly, better drug education in schools worldwide to make people aware of the effects and keep them safe. i've always struggled to understand how we have understood and adopted a safe-sex attitude to sex education instead of abstinence only (well at least in most of europe) but we can't do this with drugs. my school drug education consisted of "don't do it, drugs are bad, mmkay" and the horrible talk to frank scheme. i was left with the impression that all drugs cause krokodil-style effects, luckily i wised up on my own.
What they were answering
altersuperid · 1 points
Okay, so that's what magnesium glycinate is. What does it have to do with MDMA?
u/MisterYouAreSoDumb
Ohh, you just aren't sure why one should take magnesium in the first place. That is one of the quintessential supplements when taking ANY stimulant. Stimulants that work on the serotonin, dopamine, and norepinephrine system can cause excitotoxicity by causing your gated ion channels to remain open for too long, allowing calcium, sodium, and potassium to pass through the channels in too high of quantities and/or frequencies. Calcium is the main problematic one. This can damage your neurons. Magnesium is a voltage-dependent NMDA receptor antagonist. This means that it prevents your NMDA receptors from keeping your ion channels open for too long, but still allows them to operate normally. This is different than taking a total NMDA receptor antagonist like ketamine. NMDA excitotoxicity also controls your tolerance to many drugs. Taking magnesium along with inositol will help to lessen your tolerance to stimulants like MDMA and Amphetamine.
So in short, take a highly bioavailable magnesium supplement, like magnesium glycinate, so that your can prevent excitotoxicity, as well as slow your tolerance build up. You will also notice that you do not grind your teeth or chew on your cheeks nearly as much. It will also make it easier to pee.