Comment · Sat, May 17, 2025 · ND Owner
Make L-Citrulline MUCH better by adding Glutathione
Original post in this thread
Semtex7 · 74 points
TLDR: title
Ok, quick and dirty today boys (hopefully). I had mentioned somewhere that you can potentiate L-Citrulline substantially by adding Glutathione (reduced) to it and got a bunch of DMs. So I prefer answering this via one single post for everyone.
There are a lot of studies examining the Glutathione effect on nitric oxide and other relevant markers, but for this post I am not gonna analyze a bunch of them. I will focus mainly on one paper that is actually incredible.
(Here I delayed the post because the server of the journal went down and I didn’t want you to just trust me, I eventually got tired of waiting so I am linking the pubmed article on the paper)
We all know why L-Citrulline is better than L-Arginine - better absorbed by the body, yada yada, I will spare you the details as virtually all of you are familiar with them.
Glutathione is a low molecular weight, water-soluble tripeptide composed of the amino acids cysteine, glutamic acid, and glycine. Glutathione is an important antioxidant and plays a major role in the detoxification of endogenous metabolic products, including lipid peroxides. Intracellular glutathione exists in both the oxidized di…
What they were answering
chris106 · 1 points
I'll have to give that combo a try. On a different note - how would you say Citrulline and Arginine + Glutathione compare to Citrulline Malate or AAKG?
"Regular" Citrulline or Arginine never worked as well for me in terms of vascodilation as CM or AAKG. At least not in the standard doses.
Furthermore, would adding Glutathione to CM or AAKG give an even higher boost? Or would it likely not work that way, as they are already bound to Malic Acid / AKG - already doing the same job as Glutathione in that regard?
u/MisterYouAreSoDumb · ND Owner
I think citrulline malate and AAKG are better if you are working out or doing stressful activity like hiking/mountain biking. I am mostly working at a desk these days, so citrulline and arginine work well as a daily maintenance sort of thing. Adding glutathione in with citrulline malate or AAKG would absolutely be a good idea.