Comment · Wed, May 7, 2025 · ND Owner
Make L-Citrulline MUCH better by adding Glutathione
Original post in this thread
Semtex7 · 74 points
TLDR: title
Ok, quick and dirty today boys (hopefully). I had mentioned somewhere that you can potentiate L-Citrulline substantially by adding Glutathione (reduced) to it and got a bunch of DMs. So I prefer answering this via one single post for everyone.
There are a lot of studies examining the Glutathione effect on nitric oxide and other relevant markers, but for this post I am not gonna analyze a bunch of them. I will focus mainly on one paper that is actually incredible.
(Here I delayed the post because the server of the journal went down and I didn’t want you to just trust me, I eventually got tired of waiting so I am linking the pubmed article on the paper)
We all know why L-Citrulline is better than L-Arginine - better absorbed by the body, yada yada, I will spare you the details as virtually all of you are familiar with them.
Glutathione is a low molecular weight, water-soluble tripeptide composed of the amino acids cysteine, glutamic acid, and glycine. Glutathione is an important antioxidant and plays a major role in the detoxification of endogenous metabolic products, including lipid peroxides. Intracellular glutathione exists in both the oxidized di…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
Another one people sleep on is GABA when taking arginine and citrulline.
I usually combine L-citrulline, L-arginine, glutathione, and GABA at the same time. Increasing nitric oxide through citrulline and arginine supplementation also potentiates GABA's prolactin lowering effects.
Nitric oxide can also increase dopamine, by acting as a re-uptake inhibitor.
[Nitric oxide inhibits \[3H\]dopamine uptake](https://www.sciencedirect.com/science/article/abs/pii/000689939491818X)