Comment · Sun, August 13, 2023 · ND Owner
Why does the Infini-B complex use methylcobalamin over Hydroxycobalamin?
Original post in this thread
pinkplatapus9876 · 6 points
I’m wondering as Hydroxycobalamin is a more active form and easily converted in the body as compared to methylcobalamin.
What they were answering
RarageInTheGarage · 1 points
If not adenosylcobalamin, have you had any luck with other sources of adenosine? cAMP or precursors should work great with a dopamine stack.
IMO, alternatively-substituted cobalamins in general are a really untapped corner of biochemistry. If you can't get adenosylcobalamin though, that doesn't bode well for anything more exotic. I've been curious about glutathionylcobalamin, where glutathione bonds to B12 via on the cysteine's S end; I kinda wonder what cysteine-B12 would do in the body.
u/MisterYouAreSoDumb · ND Owner
Our cordyceps actually has high adenosine levels. The issue is that I am not sure if it is orally bioavailable. A study even tried supplementing ATP and found it did not increase blood levels, but did increase uric acid, which is not ideal.
Now that is ATP, not adenosine itself. Then there was another study that showed benefits with exogenous ATP supplementation.
So there is conflicting information. Cordycepin is an adenosine derivative, and there are other adenosine derivatives in cordyceps that I think are active orally. Truthfully, I have not personally tried adenosylcobalamin, so I can't comment on how much more effective it is. Maybe I need to.