Comment · Wed, December 21, 2022 · ND Owner

Any information on how this applies (or doesn’t apply) to ND’s ALCAR?

What they were answering

Direct reply to the original post in this thread.

u/MisterYouAreSoDumb · ND Owner

TMAO is created by gut bacteria metabolizing things like carnitine and choline in the large intestine. The issue with taking normal L-carnitine is that only 14-18% gets absorbed through passive transport, with the rest being broken down by the gut microbiome. That's where the TMAO can be created. ALCAR is able to absorb through active transport, though. This should result in less risk of your microbiome metabolizing it into TMAO. Also, taking berberine and vitamin D can help lower TMAO, so you can take those alongside ALCAR.

Vitamin D Decreases Plasma Trimethylamine-N-oxide Level in Mice by Regulating Gut Microbiota

Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation

Other MYASD lines in this thread

Comment · Fri, December 23, 2022 · 2 pts
L-carnitine tartrate is just a salt of carnitine and tartaric acid. It will dissociate in solution in the GI tract, so it will act similarly to regular L-carnitine once it hits the large intestine.

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