Comment · Sat, December 3, 2022 · ND Owner
Cognance sublingual?
Original post in this thread
mrjasonbbc · 11 points
Is there any absorption advantage with cognance bypassing first pass metabolism sublingually?
I've taken 100mg the past four mornings. The effects do seem to accumulate each day especially taken with Happy stack and 10% HGW. Yesterday especially I was on such a good mood and so far today it's the same. Looking forward to where this leads!
What they were answering
mrjasonbbc · 3 points
I appreciate the response! I share the same sentiment IRT the science not having the full picture - and how enough anecdote can raise questions about the science, especially "what are we missing?" Look at something like tongkat. I haven't seen anything in literature alluding to the so called "crashed estrogen" symptoms plenty of users have reported. But when you look at the MOA it's totally plausible and anecdote backs it up. I do not have a formal biochem or pharma background, but I picked up all I know by working backwards from stimulus and effect and having that as context behind the explanation of the science. It's the same in my line of work - we can simulate 90+% of the outcomes of a series of simulated events in Matlab and other sim software, but we need the real life recursive functional testing to uncover what we're missing. It really piques my interest exploring a new substance like Cognance, gaining a basic understanding of what the science knows "so far" about its potential effects, and quietly observing what others report. I'm really looking forward to 4-6 weeks from now and just keeping the early reports in my back pocket unless there are many consistent reports of the same SPECIFIC effects.
Anyways I'll gladly volunteer myself as a guinea pig for the next week to trial sublingual dosage.
u/MisterYouAreSoDumb · ND Owner
It's the idea that where there is smoke, there is usually fire. If you see smoke on the horizon, you don't say to yourself: "Huh, I was told there was no fire, so I guess there isn't!" No, you go try to find the source of the smoke, just in case their is a fire nobody knew about. That's how anecdotes and self experimentation works. If enough people try something and get the same effect/side effect, perhaps we should try to work backwards and find a possible mechanism for that. If a research paper said a specific forest couldn't catch on fire, but right in front of your eyes you saw a massive amount of smoke coming from said forest, you would be nuts to just write it off as some unexplained phenomenon instead of actually going to try and track down a possible fire!