Comment · Tue, August 23, 2022 · ND Owner
why isn't ecdysterone complexed with cyclodextrin?
Original post in this thread
samuelx23 · 10 points
So the literature seems to indicate that ecdysterone has low water solubility and thus low abortion orally. When conplexed with beta cyclodextrin it seems to have much high solubility and theoretically higher bioavailability. Because of this I wonder why ND doesn't sell a complexed version? Although I know guerilla minds turkesterone is controversial there product is supposedly complexed this way. Anecdotally I found this to give massive benefit. Are you guys taking higher doses of 20E to account for this? Am I missing something?
Poor bioavailability
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.mdpi.com/2227-9059/9/5/492/pdf&ved=2ahUKEwjlusOj2tr5AhXrk4kEHcn6BFMQFnoECAcQAQ&usg=AOvVaw1UaFF8k25MHizLT2OvG1yA
Compmexex cyclodextrin and 20E has better water solubility
https://pubmed.ncbi.nlm.nih.gov/30458190/
In vitro simulation of stomach environment increased absorption
https://pubmed.ncbi.nlm.nih.gov/35311602/
What they were answering
samuelx23 · 2 points
Thank you for clearing it up for me
u/MisterYouAreSoDumb · ND Owner
My pleasure! If you could hear the conversations my scientific team and I have, you'd realize just how ridiculous this industry is. Everyone just makes shit up and uses buzzwords. Liposomes, cyclodextrins, hydroxypropyl beta cyclodextrin inclusions complexes, enhanced bioavailability matrices... The newest one that's going around is cyclosomes. It's a cyclodextrin complex encased by a liposome! It's like Xzibit got into the marketing department. Yo dawg, we heard you like encasing things in shit, so we put your vitamin C inside of a cyclodextrin, then put that inside of a liposome!
"But isn't vitamin C perfectly bioavailable on its own?"
"Shut up! It's better, okay!"
I am all for advancing and making improved versions of things. However, it has to be based in science... and not based in science like they read one research study and then bought a random batch from China claiming to be the same thing. It has to be properly validated in the lab. I bet if Huberman went on Rogan again and said the next biggest thing was beta-ecdsyterone craprosomes, Chinese suppliers would be offering it within days. Cyclodextrins are out... We are doing craprosomes now!
"I don't even know what that means!"
"No one knows what it means, but it's provocative!"