Comment · Wed, August 10, 2022 · ND Owner
🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬
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NootropicsDepotGuru · 16 points
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Share your most treasured research studies with us! Each Wednesday, we round up our favorite research study discoveries to share and discuss with the community on r/NootropicsDepot. Discover new studies, dig deeper into research, and present your findings from research studies about supplementation, nootropics, health, and fitness here on our weekly discussion thread.
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u/MisterYouAreSoDumb · ND Owner
Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro
The mRNA expression levels of RSC96 cell‑specific genes were determined by RT‑qPCR analysis. Nerve growth factor (NGF) and several neurotrophic factors, including BDNF, GDNF and CNTF, have key roles in Schwann cells and the regeneration of peripheral nerves. The mRNA expression levels of BDNF, GDNF and CNTF were significantly increased in the Andrographis-treated groups compared with the control group (Fig. 7) except for BDNF levels at 6.25 μM concentration. Furthermore, among all of the groups, 3.125 μM Andrographis exhibited the best effect on upregulation of BDNF, GDNF and CNTF.
Andrographis increases BDNF, GDNF, and CNTF!