Comment · Thu, June 9, 2022 · ND Owner
New NMN enteric tablets and flushing/itching?
Original post in this thread
OPengiun · 5 points
Recently received a second bottle of the enteric NMN tablets and noticed they are differently shaped than the previous order (more rounded and spherical).
With the first bottle, I did not notice any type of flushing or pin-prickling feeling, however am since I started this new bottle. It feels exactly like a niacin flush.
It may be unrelated completely, but is it possible that NMN can cause a niacin like skin flush?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
Your body could be converting more of the dose to niacin.
If you are having higher levels of NRK1,2, then you can be making more nicotinamide riboside (NR) from the NMN. Then your purine nucleoside phosphorylase (PNP) enzyme can convert that to nicotinamide/niacinamide (Nam). Then your nicotinamidase (pncA) enzyme can convert it to niacin. Normally the preferred pathway for NMN is through NMNAT to NAD+. However, some can convert to NR, which then often does go the other direction. Usually that then gets converted by NAMPT to NMN again, but maybe yours is going the other way as well. Of course some people can flush with just niacinamide, so it wouldn't need to take that lest step necessarily. It could be jumping to NR then Nam and causing flushing.