Comment · Thu, June 2, 2022 · ND Owner
berberine capsules
Original post in this thread
AlwaysWGrace · 5 points
u/misteryouaresodumb Any chance berberine capsules or even tablets again? Although i was thrilled to have a trusted source for the powder again turns out I absolutly hate making my own.
What they were answering
Jazzlike_Fan232 · 2 points
I have taken it by itself and I feel the effects.
u/MisterYouAreSoDumb · ND Owner
Regular berberine works, even though berberine itself has low bioavailability. This is because the probiotics in your system convert it to dihydroberberine, which then absorbs well, and is then converted back into the active berberine form.
https://www.nature.com/articles/srep12155
This study shows that the gut microbiota can act as an “organ” that converts BBR into dhBBR in the intestine via a reduction reaction mediated through bacterial nitroreductase. DhBBR, which was found to be absorbable by the intestinal epithelia, was reverted to BBR (the active form) immediately after entering the intestinal wall tissues. The reversion of dhBBR to BBR via oxidization occurred mainly through a non-enzymatic reaction in intestinal epithelial tissues, with the participation of multi-faceted factors such as superoxide anion and metal ions.