Comment · Thu, June 2, 2022 · ND Owner
berberine capsules
Original post in this thread
AlwaysWGrace · 5 points
u/misteryouaresodumb Any chance berberine capsules or even tablets again? Although i was thrilled to have a trusted source for the powder again turns out I absolutly hate making my own.
What they were answering
KodiakDog · 1 points
Is berberine one of those compounds that’s best taken in an enteric tablet? I’ve read that by itself it’s supposed to have shit bioavailability.
u/MisterYouAreSoDumb · ND Owner
No, berberine is not susceptible to stomach acid. Also, your microbiome converts it to dihydroberberine to absorb, then converts it back to active berberine in the cell walls before entering the blood stream.
https://www.nature.com/articles/srep12155
This study shows that the gut microbiota can act as an “organ” that converts BBR into dhBBR in the intestine via a reduction reaction mediated through bacterial nitroreductase. DhBBR, which was found to be absorbable by the intestinal epithelia, was reverted to BBR (the active form) immediately after entering the intestinal wall tissues. The reversion of dhBBR to BBR via oxidization occurred mainly through a non-enzymatic reaction in intestinal epithelial tissues, with the participation of multi-faceted factors such as superoxide anion and metal ions.