Comment · Sun, March 20, 2022
Experimental ROAs, Oral Preparation
Original post in this thread
zalgorithmic · 1 points
Hello all, I’ve acquired some cerebrolysin from cosmic and obtained needles and such for IM usage. I have no phobia per se of doing an injection (and I will be trying IM at some point) but it seems like a bit of a hassle.
It is said that cerebrolysin would be useless or ineffective when taken orally, but I have seen reports of sublingual usage that seem promising. Has anyone found this ROA to be effective? Additionally, I have found a study showing positive cognitive changes from a single oral 30mL dose in elderly patients, which would suggest it’s not impossible to take orally, but perhaps wasteful.
I’m aware of the Memoprove product, but can’t find any information about the process they’ve used to make it orally active. Does anyone have references on their encapsulation process?
As far as a DIY prep, I have been researching other papers which investigate peptide preparations wherein the protein/peptide is encapsulated in some sort of polysaccharide to stabilize it against the stomach, and then release it in the lower intestine. One simple way to do this would be to mix cerebrolysin with 2% sodium alginate, possibly + 2% polyvinyl…
What they were answering
zalgorithmic · 1 points
/u/Misteryouaresodumb I'd love to hear your thoughts on this (if you've got the time, however brief). I can link additional studies on similar blends. There's one in particular I remember seeing that proved this sort of composition prevented gastric bleeds from an NSAID active by preventing release in the upper gastrointestinal tract. I do not have knowledge/experience with peptides like you, so I don't understand the intricacies of absorption and could greatly benefit from your take on this general idea.
u/MisterYouAreSoDumb
That's an interesting possible solution using the sodium alginate. Do you have any data showing that getting it to the small intestine intact will provide more bioavailability, though?