Comment · Fri, April 2, 2021 · ND Owner
Bloodwork (on Tongkat Ali)
Original post in this thread
ConstantLi · 81 points
EDIT: Link to bloods
https://imgur.com/a/iEE9heg
Hi everyone,
Been a longtime buyer from ND, always appreciated the high quality, but never made a post on the subreddit.
So I'm in my 20s, got my testosterone tested earlier this year before the pandemic and scored a disappointing 388. Doctor refused to do any more hormone testing to see if anything was wrong because I was in range.
So then I started optimizing my own health. Supplemented vitamin D, magnesium, and zinc. Stopped eating out and buying frozen meals. Cut out drinking bottled water, which may leech plastics. Getting plenty of sunlight. Ate lots of healthy fats.
And I started taking ND's 10% Tongkat Ali. Been taking it for the last month and a half. Took another testosterone blood test at a men's clinic last week and scored 972.
Now of course, I can't say it was 100% due to Tongkat. I made a lot of lifestyle changes as you can see since my last test. But what I will say is my new doctor was really surprised how big of a jump I made in half a year. And this isn't even the highest I could go, since I usually don't have great sleep and recently I haven't been getting as much exercise as I should. Now my next goal is…
What they were answering
johnnycoconut · 1 points
Probably similar.
But in a hypothetical world where only the S isomer of modafinil affected histamine, armodafinil wouldn't, and racemic modafinil would presumably affect histamine like half that dose of S-modafinil. Adrafinil, being racemic and metabolizing into modafinil, would also affect histamine.
(But I think what you're getting at is that R-modafinil affects histamine. Does S-modafinil also affect histamine?)
u/MisterYouAreSoDumb · ND Owner
I mean, in theory the histamine thing could be enantiospecific. This would have to be some sort of enzyme interaction where one isomer could bind to the enzyme and the other can't. That does happen with some things, so it is not out of the realm of possibility. However, usually that happens more with conformational/cis/trans isomers than optical isomers like adrafinil/modafinil. I believe most of the histaminergic effects of the afinils are due to their modulation of the dopamine system, which causes a downstream release of histamine from the hypothalamus. This should happen with both R and S modafinil. It could happen more with R, as it has higher dopamine affinities. However, I would imagine there is some histamine effects from the S isomer as well.