Comment · Thu, March 4, 2021 · ND Owner
Sabroxy Capsules Coming?
Original post in this thread
verifitting · 20 points
I'm really glad the powder is out but I definitely prefer capsules for ease of use. Has ND determined a good dosage for what caps will be? If yes, what dosage; and will the caps be for sale any time soon?
Just being impatient but will buy once they are out :)
Cheers
What they were answering
sirsadalot · 2 points
Yeah I get it. I've only tried 500mg Sabroxy, can't say I've come close to 500mg pure Oroxylin-A yet. I'm not sure if you were referencing pure Oroxylin-A this whole time because if so, yeah 500mg sounds nerve-racking.
If I'm understanding Oroxylin-A correctly, it's an antagonist at the benzodiazepine site. Perhaps Magnolia Bark then at a dose that mostly nullifies it at GABA-A. That might be too sedating, however, if you take the 10% extract because of the Baicalein.
u/MisterYouAreSoDumb · ND Owner
I was just referencing pure oroxylin-a because we know what pure caffeine does. That's not the doses I was actually taking. Sabroxy is ~10% oroxylin-a. We are working on a pure oroxylin-a product too, because I think it will be interesting to see how that works in isolation without all the other stuff in the extract. I think the baicalin in Sabroxy is definitely affecting things as well.
It's a negative allosteric modulator, so similar to an antagonist but not the same. Funny enough, I tried Sabroxy with magnolia bark yesterday and I really liked the combo. I think we are on to something with targeting GABA at the same time to smooth it out.