Comment · Mon, February 22, 2021 · ND Owner
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Original post in this thread
NootropicsDepotCom · 45 points
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What they were answering
Aldarund · 1 points
But trasn and cis for mk-7 is all over papers. For example https://link.springer.com/article/10.1007%2Fs00253-020-10409-1
And in this paper they measure even cis and trasn in mk 7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429189/
Two recent publications \[19,20\] highlighted that the indications of the USP monograph showed important limitations in terms of purity profiling and are subjected to risk of overestimation since several cis\-trans isomers cannot be distinguished from the all-trans active form with conventional chromatographic techniques. Using a combination of high-resolution mass spectrometry and quadrupole-time of flight (HRMS-Q-TOF) for the identification and charged aerosol/diode array detectors (CAD/DAD) for the quantification, Szterk et al. \[19\] observed that out of seven supplement formulations from the European and U.S. market, most had a lower content in active MK7 all-trans in association with relevant, in some cases major, content of inactive cis\-trans isomers and other n…
u/MisterYouAreSoDumb · ND Owner
I am just explaining to you the proper usage of the terms. This is what USP's reference standard is called.
((all-E)–2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione)
That's straight from USP, which is what we use as a reference standard. It's not called cis and trans. The proper term for it is "all E" if you are being scientifically precise. Even if you just look at the IUPAC name, you see 2E, 5E, 9E. Here is how it looks if you write out the full IUPAC name.
2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
Those double carbon bonds result in many different stereocenters. From a scientifically precise stance, cis and trans only come into play when the configurational isomerism results in exactly two distinct forms. That's not the case with MK-7. Those papers are misusing the term.