Comment · Tue, February 9, 2021 · ND Owner

Will the piperine in the enteric coated EGCG capsule affect absorption of medications?

Original post in this thread

redditinface · 14 points

I'd love to take ND's EGCG cap, and what I'm hoping is that because it's enteric coated I can take it along with a couple of medications in the morning (finasteride and tamsulosin), and by the time the EGCG/piperine gets to my intestines the piperine will no longer affect the metabolism of the meds.

Does that sound like a reasonable hypothesis?

What they were answering

redditinface · 5 points

Thanks. I just did a little googling and decided it wasn't worth the risk, since "Concomitant exposure to potent CYP3A4 inhibitors can more than double the exposure of tamsulosin," and at least in one case, coadministration of piperine can affect medication-related outcomes for at least 24 hours. So, you know, abundance of caution and all that. Would love to get a version without the piperine though!

u/MisterYouAreSoDumb · ND Owner

Agreed. Sometimes the potential for interaction is not worth the risk.

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