Comment · Fri, October 9, 2020 · ND Owner
When is the Vitamin D3/K2 Formula coming out?
What they were answering
Aldarund · 2 points
Might give some insights. Seems like mk7 not so stable
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429189/
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In general, menaquinones, while showing a very high thermal stability, may be degraded following exposure to UV radiation and alkaline compounds \[23\]. It is very likely that magnesium oxide-associated instability is associated with alkalinisation, which appears to be remarkably effective in accelerated stress conditions in the presence of higher relative humidity (75%).
Interestingly, the destabilizing effect of the minerals was not identical in the presence of different MK7. In fact, the synthetic compound (PII) had already halved the MK7 content, in either the presence of L-Arg or MgO, after one month in standard conditions (p < 0.001), and, in general, all the tested compounds produced a significant decrease in stability, well below 90%, after 12 months in standard testing conditions (p \> 0.001). In accelerated stress conditions, the stability profile of synthetic MK7 was worsened, showing an already highly significant decrease of MK7 in the presence of calcium salts after 1 month of storage (p < 0.001). Enhanced degradation was also observed for naturally fermented MK7 (PIII). In this case, degradation was als…
u/MisterYouAreSoDumb · ND Owner
Yep, we knew about the stability. Our MK-7 has been in the lab freezer since arriving. The issue is either that it degraded in shipping to us, or it degraded after sampling. This was hard to determine at first, because we had to develop our own MK-7 analytical methods. So the measurement could have been from a method error, or it could have just been a degraded sample. So we had to do more validation work to ensure it was not our analytical method that was leading to a false negative.