Comment · Tue, September 15, 2020 · ND Owner
Ca-akg
Original post in this thread
Darkhorseman81 · 8 points
I know I spam this page with occasional requests, and apologies if its annoying, but.
Any plans to release calcium akg? I notice you already have Aakg.
Read a few studies on its beneficial effects, recently!
What they were answering
Darkhorseman81 · 8 points
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice(study uses calcium form, but is also sponsored by someone trying to sell it)
https://www.biorxiv.org/content/10.1101/779157v1.full
https://newatlas.com/health-wellbeing/healthspan-anti-aging-akg-animal-study-human-trials/
The modern obesity epidemic is more than just Sugar, Salt, and lack of fiber. There is a fairly prevalent metabolic disorder that is driven by aberrant phosphate metabolism, which this seems to help correct, among other things.
https://europepmc.org/article/med/8676818
The effect of alpha-ketoglutarate (AKG) on the behavior of ageing laboratory mice
http://rn.ptz.icm.edu.pl/wp-content/uploads/2018/07/Niemiec-ang_.pdf
Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice
http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.agro-ee6193a5-27f2-4bb3-a610-a5fea192f25a/c/14.pdf
There are a bunch of Polish studies, but I CBF translating them.
I am planning to add it to a protein powder I am developing, quite specifically, for the elderly.
This, something that regulates TFAM for MTDna restoration, something that targets aberrant Methionine…
u/MisterYouAreSoDumb · ND Owner
So it seems it is the alpha-ketoglutarate we care about. We already have AAKG, which is L-arginine alpha-ketoglutarate. Honestly, calcium is one people need to be careful with, as getting calcium too high in certain parts of the body/brain can cause issues. I had this when I used calcium BHB salts, whereas I did not have it with potassium BHB. A more productive counter-ion like L-arginine makes more sense to me. I suppose we could investigate other counter-ions to pair it with. Hell, we could get really creative with it. I already have a bunch of ideas. I will speak to the team about it.
https://nootropicsdepot.com/aakg-2-1-powder-l-arginine-a-ketoglutarate/