Comment · Wed, September 9, 2020 · ND Owner
Any plans to stock quercetin?
Original post in this thread
[deleted] · 11 points
I love it for allergies and anti oxidant properties
What they were answering
[deleted] · 2 points
Interesting to see this:
In conclusion, moderate daily supplementation of healthy young humans with graded concentrations of quercetin for 2 wk dose-dependently increased plasma quercetin concentrations but did not affect parameters of antioxidant status, inflammation, and metabolism.
u/MisterYouAreSoDumb · ND Owner
They explain why that might be.
There are several reasons that may explain the lack of effects on parameters of oxidant/antioxidant status. First, in our protocol, plasma concentrations of quercetin (Q150, 380 nmol/L) may have been too low to improve the plasma antioxidant status. In fact, quercetin concentrations were below those shown to be effective in in vitro assays (39). Second, our subjects were young, healthy, and had an adequate dietary intake of essential antioxidants (vitamins E, C, β-carotene). In addition, they did not smoke or perform excessive physical exercise. Accordingly, plasma tocopherol and serum concentrations of cardioprotective HDL cholesterol were high in our volunteers (Table 1). Hence, an effect of quercetin to improve biomarkers of oxidative stress in our subjects was unlikely to occur. Third, flavonoids, such as quercetin, are carried in rat and human blood by serum albumin in the form of complexes between albumin and quercetin 3-O conjugates (mainly glucuronides and sulfates) (40,41). At present, antioxidant activity of quercetin metabolites bound to albumin is unclear.