Comment · Sun, April 19, 2020
Nootropics Depot Schisandra Chinensis Extract - CYP3A4 Inhibition?
Original post in this thread
CyberTheBoss · 6 points
According to this paper (https://www.ncbi.nlm.nih.gov/pubmed/15342469), gomisin C is an irreversible inhibitor of CYP3A4. I was considering purchasing the Schisandra extract but I'm concerned about irreversible inhibition of CYP3A4 due to a medication I take. Does the ND extract contain significant amounts of gomisin C or other CYP3A4 inhibitory compounds? Unless I get an answer I'll probably just leave it out of my cart to be safe, but I'm intrigued due to some of the anecdotes I've heard.
What they were answering
CyberTheBoss · 3 points
If I want liver protection I'll stick to NAC, I'm just worried about metabolism of this specific medication which I know is metabolized primarily by CYP3A4 into its major active metabolite.
u/MisterYouAreSoDumb
For sure. I just found it while searching for info on CYP3A4 and schisandra, and found it interesting.