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Comment · Mon, March 16, 2020

What do the makers of Nootropics take themselves?

Original post in this thread

varvela · 23 points

To the team at Nootropics Depot, I’m curious to know what are some in-house favorites among the products you sell?

What stacks do you guys take that drive development of such great products?

What they were answering

ShouldReallyGetWorkn · 1 points

Wow, super interesting! What are you guys planning to do with all the COVID-19 research?

Didn't know Lutein had all these other effects on organ systems, I've just been skipping straight to the eyes part. That's actually pretty nifty.

I just ordered a Lutein/Zeaxanthin combo from NOW to try out for my eyes, now I have even more reason to take it lol.

That last study you linked is quite well written, easy to read and great explanations on strategies for finding new drugs in the intro. I'm tickled that under the PLPro inhibitors, #4 is aspartame. It would be funny if tossing back 2L's of Diet Coke protects you from COVID-19. Also interesting is famotidine at #5 3CLPro inhibitor, so I can take that too since all that soda is gonna give me heartburn.

They mention hesperidin several times--I feel like there was an ND product with that also.

u/MisterYouAreSoDumb

Wow, super interesting! What are you guys planning to do with all the COVID-19 research?

Help our family, friends, and coworkers manage it better to help prevent them from getting it, or help them fight it off if they do. We are trying as hard as we can to ensure our team stays healthy, and that our operation keeps going. Understanding what we are dealing with is the first step to being able to do that. If you wait for the official government word on things, you are going to be way behind or misled. It's better to go to the source, and read the research coming out by the day.

That last study you linked is quite well written, easy to read and great explanations on strategies for finding new drugs in the intro. I'm tickled that under the PLPro inhibitors, #4 is aspartame. It would be funny if tossing back 2L's of Diet Coke protects you from COVID-19. Also interesting is famotidine at #5 3CLPro inhibitor, so I can take that too since all that soda is gonna give me heartburn.

That would be kind of funny! I know a lot of people are speculating right now about anti-inflammatory compounds hurting, but many people are misinterpreting the research. COVID-19 has a two-stage inflammatory response. The initial inflammatory response is what is needed to properly fight off and clear the virus from the lungs. However, once it passes that stage, your inflammatory response is correlated with more pneumonia. So anti-inflammatory things actually help once you have it, as they help prevent the pneumonic reaction. You just need to make sure the specific anti-inflammatory does not up-regulate ACE2. This is why taking Ibuprofen is bad in the early stages because it up-regulates ACE2. Well ACE2 is what the virus is using to enter and infect your lung cells. So it makes you more likely to get COVID-19, and for it to spread. ACE2 is also up-regulated in smokers, which is why they are especially at risk.

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