Comment · Thu, January 23, 2020
PRL-8-53 mechanism details?
Original post in this thread
Clide024 · 8 points
Took 5mg of PRL-8-53 for the first time two days ago, followed by another 5mg a few hours after that. Experienced a short-lived, fairly mild feeling of enhanced engagement with the tasks I was doing, followed by a very lengthy comedown that was akin to what I'd expect from using dopaminergic recreational drugs (I've abstained from all substances of abuse for over 2 years now).
Yesterday I tried taking 5mg again, and experienced the same thing, but the after effects were still quite strong this morning, and are still lingering over 24 hours after. Taking some l-tyrosine and DLPA earlier seemed to help for a time. This is the only other anecdote I've found that's similar to this experience.
The Examine page describes PRL-8-53 as a dopamine agonist. Is there any further information available? If the substance itself is a dopamine agonist, could this feeling be caused by a downregulation of dopamine receptors? Or could it have depleted dopamine precursors? I'd be surprised if something with such a sho…
What they were answering
johnnycoconut · 1 points
What do you think of the hypothesis that it's an HDAC inhibitor?
u/MisterYouAreSoDumb
It's possible, but everyone is just speculating at this point. It's also likely not a single mechanism. HDAC inhibition could be a part of a larger set of affinities. I do see the connections he is making, though.