Comment · Fri, January 10, 2020
PRL-8-53 mechanism details?
Original post in this thread
Clide024 · 8 points
Took 5mg of PRL-8-53 for the first time two days ago, followed by another 5mg a few hours after that. Experienced a short-lived, fairly mild feeling of enhanced engagement with the tasks I was doing, followed by a very lengthy comedown that was akin to what I'd expect from using dopaminergic recreational drugs (I've abstained from all substances of abuse for over 2 years now).
Yesterday I tried taking 5mg again, and experienced the same thing, but the after effects were still quite strong this morning, and are still lingering over 24 hours after. Taking some l-tyrosine and DLPA earlier seemed to help for a time. This is the only other anecdote I've found that's similar to this experience.
The Examine page describes PRL-8-53 as a dopamine agonist. Is there any further information available? If the substance itself is a dopamine agonist, could this feeling be caused by a downregulation of dopamine receptors? Or could it have depleted dopamine precursors? I'd be surprised if something with such a sho…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
I am not sure why Examine says that. If you read the full study they cite for that, there is nothing in there about it being a dopamine agonist. It says that it elevated compulsive gnawing in rats, but that is in no way evidence of its receptor affinities. Nikolaus Hansl never fully released the manuscripts discussing his opinions on the possible mechanisms. My personal opinion is that it is a positive allosteric modulator of ACh and DA, but that is not fully proven.