Comment · Thu, October 12, 2017

This amazing MDMA damage mitigation post by /u/MisterYouAreSoDumb is four years old now. Have there been any discoveries since that warrant an update?

What they were answering

carclaze · 2 points

According to PhD neuroscientist and 20-year MDMA researcher /u/MBaggott, it is unlikely that MDA is a significant contributor to MDMA neurotoxicity at common doses. He even gave MDA to volunteers in this study.

u/MisterYouAreSoDumb

Yes, I've gone back and forth with him via PM on it before. I still have not been given any conclusive evidence to the contrary; at least to my personal satisfaction. I still think that the MDA metabolites, glutathione and N-acetylcysteine conjugates of α-methyldopamine, are the primary cause of neurotoxicity. Again, I could be totally wrong. I'd love to see some more recent studies on it to confirm/deny. I'd rather be wrong and know the truth, than think I'm right based on faulty evidence.

Glutathione and N-Acetylcysteine Conjugates of α-Methyldopamine Produce Serotonergic Neurotoxicity: Possible Role in Methylenedioxyamphetamine-Mediated Neurotoxicity

2,5-bis-\(Glutathion-S-yl\)-α-methyldopamine, a putative metabolite of \(±\)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

The Role of Metabolism in 3,4-\(±\)-Methylenedioxyamphetamine and 3,4-\(±\)-Methylenedioxymethamphetamine \(Ecstasy\) toxicity

Serotonergic Neurotoxic Metabolites of Ecstasy Identified in Rat Brain

Neurotoxicity mechanisms of thioether ecstasy metabolites

Accumulation of Neurotoxic Thioether Metabolites of 3,4-\(±\)-Methylenedioxymethamphetamine in Rat Brain

If you read through all those studies, and come to a contrary conclusion to me, by all means let me know.

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Comment · Sat, October 7, 2017 · 10 pts
This is the main study I was referencing in my post: [Non-linear pharmacokinetics of MDMA \(‘ecstasy’\) in humans](http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2000.00121.x/full) [Here is the figure.](http://

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