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Comment · Mon, April 27, 2015 · Ceretropic

Safety of taking racetams with tianeptine

Original post in this thread

[deleted] · 3 points

I recently decided to take tianeptine (15mg-20mg) with my normal stack of oxiracetam (800mg) and aniracetam (800mg) without considering potential contraindications.

Could I have caused any brain damage in the form of excitotoxicity? I've read *racetams normalize NMDA and AMPA, while I'm not sure exactly what role tianeptine plays. That would indicate to me my worries are probably unfounded, but, then again my basis rests in casual googling.

Thanks.

edit: I should mention I took aniracetam on an empty stomach then ate. So I'm not sure what my effective dose really was.

What they were answering

bob000000005555 · 1 points

~~I think this may be toxic since tianeptine regulates NMDA and AMPA receptors, while oxiracetam is a NMDA agonist and aniracetam is an AMPA agonist. You could try asking /u/MisterYouAreSoDumb, I had a similar question he resolved.~~

u/MisterYouAreSoDumb · Ceretropic

Neither of them are agonists. Oxiracetam is a positive allosteric modulator of the NMDA receptors, and Tianeptine is a signal transduction modulator of AMPA/NMDA currents. Tianeptine actually prevents stress-induced over-activation of the NMDA receptors. So it would be protecting you from excitotoxicity.

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