Comment · Sat, July 19, 2014
Question about MDMA and 2C-B supplementation
Original post in this thread
30792581 · 16 points
Sorry for my ignorance on these matters, and thanks in advance for any advice. I'm planning on following the below supplement routine for an upcoming MDMA roll:
Before:
100 mg Co Q-10
800 mg Magnesium Glycinate
1200 mg Vitamin C
400 mg Acetyl L-Carnitine HCL
100 mg Grape Seed extract
200 mg Alpha Lipoic Acid
After:
800 mg Magnesium Glycinate
1200 mg Vitamin C
400 mg Acetyl L-Carnitine HCL
100 mg Grape Seed extract
200 mg Alpha Lipoic Acid
10 mg Melatonin
Next day and daily for the following week:
100 mg HTP
1. Any suggested tweaks?
2. I doubt I'll be able to time my pre-supplement all that precisely - I'll be at a music festival, so I don't want to be carrying around handfuls of pills with me, and I also don't want to drop before I'm in front of a DJ I really love. I'll most likely supplement at camp before leaving for the night, which will probably be 2-4 hours before I drop (rather than the recommended 1 hour). With that in mind, should I switch anything up? Is there anything in my list that's going to be a guaranteed waste if I take it a few hours in advance?
3. I'm planning on doing 2C-B my first night, followed by MDMA (and possibly another bit of 2C-B) the…
What they were answering
Sigfund · 1 points
To be fair to /u/MisterYouAreSoDumb, he goes into further detail in his post about MDMA metabolism. He doesn't mean that MDA itself is more neurotoxic just that MDA metabolites are more neurotoxic, which I believe is proven though I may be mistaken.
I'm also fairly certain that grapefruit juice is a potent inhibitor^(Wikipedia but still) of CYP3A4.
Overall I don't see any reason not to pre-load/post-load especially with the anecdotal reports behind it. It's unlikely to do any harm and reasonably likely to benefit you. Though I do agree none of it is definite.
u/MisterYouAreSoDumb
MDA is MUCH MUCH more neurotoxic than MDMA. There is no doubt about that. You need to inhibit CYP2D6 when taking MDA, and figure out a way to prevent the ring-hydroxylation.