Comment · Wed, June 18, 2014 · Ceretropic
Non responder Aniracetam
Original post in this thread
[deleted] · 1 points
Hi,
I'm kind of new to nootropics but a month ago I ordered some ani and began my nootropics journey. However, I can not discriminate a distinct change or feeling when taking it. I have tried dosages ranging from 500mg to 1500mg in the morning (and topped off again at noon) but I can't really say it's working. Sometimes I think I'm a little more dreamier, when talking to people I sometimes forget super obvious words and generally throughout the day I feel rather clumsy (I forget my cellphone, my keys, etc...) but then again I think that it might be due to focussing too much on the wanted effects in a way that I make myself feel different and therefore act different. Anyone has tips? Same feelings?
My stack consists of:
- 700-1000 mg aniracetam
- 200mg theanine (+coffee) morning and lunch
- ginkgo biloba
- on days where I need to perform mentally (exams, studying): 150mg armodafinil split over the course of the day
- 5 htp for a good night's rest (not daily, serotonine syndrome scares me)
What they were answering
glabius · 0 points
I can only see the third link, however I trust your information shows something of the opposite.
From examine (usually trusted here):
4.1. Absorption and bioavailability
Aniracetam appears to be greatly taken up from the gut even in a fasted state, but is subject to extensive first pass hepatic metabolism. Due to this, it has an overall bioavailabiliy of around 8.6-11.4%.[3] Bioavailability is presumed higher when taken with fatty acids, but unexplored.
Is fat-soluble and logically enhanced when taken with fatty acids, does not appear to need fatty acids to be absorbed
Regardless I still take it with fats
u/MisterYouAreSoDumb · Ceretropic
First pass hepatic metabolism is not affected by taking lipids concurrently with aniracetam. It makes zero sense to say that fat does not help its absorption, but can enhance bioavailability in some other way. What other way is it enhancing it? The only way to bypass first pass hepatic metabolism is to use a different ROA; sublingual or intranasal for example.
You can take it with fats. It's just not helping it absorb better, and certainly does not need fat like everyone keeps parroting.