Comment · Tue, February 18, 2014

Are you overwhelmed with anxiety in social situations? MDMA.

What they were answering

Sigfund · 1 points

Grapefruit juice is a surprisingly potent CYP3A4 inhibitor, which I believe is the enzyme which metabolises MDMA into MDA which later goes to alpha-methyldopamine. So taking that may mitigate some of the neurotoxicity. ~~Pretty sure this was all conjecture by /u/misteryouaresodumb but it seems to make sense to me.~~

Edit: See his reply below.

u/MisterYouAreSoDumb

Alpha-methyldopamine has to conjugate with glutathione before it causes neurotoxicity. It does this because glutathione has transport across the BBB, which allows the oxidative substance to be uptaked into serotonin neurons.

The bergamottin in the white grapefruit juice inhibits CYP3A4, which slows the conversion of MDMA to MDA, which lowers the amount of alpha-methyldopamine that get created.

His statement that the antioxidants do nothing to protect from the damage is asinine! The Na-R-ALA has been proven to prevent MDMA induced neurotoxicity.

As does ALCAR.

And vitamin C.

It's not conjecture. I have many many studies backing it up.

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