Comment · Thu, October 17, 2013
Another LSD microdosing experiment
Original post in this thread
17ts · 472 points
Hello friends, a week ago I decided to try something losely based on Dr. Fadiman's study which motivated /u/tossed_hither for his experiment as well. I dissolved one of Jannis' yinyang dolphin 130µg tabs in 20ml dest. H2O to give me a 6.5µg/ml solution and I planned on 13µg (2ml) each morning after waking up. On two occasions I took 20µg (3ml).
I have a history of major depression, addiction and all these fun things and have discussed this with my therapist. Here's what I have gathered from my notes after 8 days:
* While the dose might not be threshold for classic psychedelic effects, I have no doubt that it is not placebo. I have tried 20µg and it starts to become slightly more psychedelic. 10-20µg seems to be perfect.
* No mydriasis. Slight texture morphing on 20µg but that might have been my ever so slight HPPD. The intensity is comparable to coffee. Time dilation seems to be present. Days feel longer.
* Mood and motivation is above average. Everything seems a little better. A sunny day is a little more sunny, leaves blowing in the wind are an incredibly complex motion and very beautiful. These little things start to become sources of happiness when they were previously ign…
What they were answering
zeekip · 0 points
Where did you get this information?
5HT2B agonism in Ki(nM) (The lower the number, the higher the affinity)
25i-NBOME : 5-HT2B (231, +/-73)
LSD : 5-HT2B = 25
u/MisterYouAreSoDumb
I thought the 5-HT2B Ki value for 25i-NBOMe was 2.3nM, not 231. At least that is what the table in this paper shows. They list it in the table as CIMBI-5 (Center for Integrated
Molecular Brain Imaging-5), as that was the name given to 25i-NBOMe during testing. Also, this paper confirms the 2.3nM number as well.