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Archive/r/WTF

Comment · Fri, September 13, 2013

Good to see this girl has entrepreneurial spirit…

What they were answering

WorldPeaceIsSoMetta · 45 points

It's a general anesthetic which is essentially a tranquilizer, in layman's terms. Enough of it and you'll pass out. Recreational users use enough to produce a strong high based around sleep resistance/ a reversing of the mechanisms used in MDMA. I've heard stories of it historically being used for human surgical operations, but have no source ATM.

u/MisterYouAreSoDumb

Recreational users use enough to produce a strong high based around sleep resistance/ a reversing of the mechanisms used in MDMA.

What? It's an NMDA receptor antagonist. It blocks the action of glutamate, preventing the NMDA channels from allowing calcium, sodium, and potassium into neurons in the brain. It does not block MDMA's mechanisms, which are pre-synaptic 5-HT2B mediated, causing reversal of the SERT.

Euphoria is mediated through the NMDA channels, though. MDMA does increase extracellular glutamate, which is part of it's euphoric effects. However, it's main mechanism is serotonin related.

Related in the archive

Commentr/WTFJun 21, 2012

Put out your beach fires properly, so I don't have to see my 3 year old niece's first day of vacation get ruined. These jerks just covered it with sand.

Replying to Pickledpaws · But it can't put out the fire... in my heart.

That's because the fire in your heart is a Class B. That requires Mountain Dew Code Red sprayed from a My Little Pony spray bottle.

201
Commentr/WTFSep 30, 2012

Playing chicken at a red light.

Replying to chagspop · And here's the [video](http://www.jokeroo.com/videos/extreme/horrible-motorbike-and-suv-frontal-crash.html), but it's the same thing. Low FPS, no audio.

Holy crap, the driver of the bike is moving at the end of the video!

83
Commentr/WTFNov 7, 2012

Artist vacuum seals couples for photo portraits

Replying to 0Simkin · Wouldn't it just be erotic-asphyxiation? I thought the auto part meant it's a solo performance.

It means you get off to blocking off the intake of Fords.

36
Commentr/WTFSep 26, 2012

What started as a tiny cut on my pinky soon escalated to this monstrosity before you within a matter of hours. Now I'll be spending a few days in the hospital getting IV antibiotics. Slightly NSFW.

Replying to dont_knockit · The speed of progression is downright scary. At least if you lose it, it's just your pinky. Sorry if that's a dim bright side, but you know it would be much worse if it were your…

Or ballsack, like the post from the other week. I tell myself that often. At least you don't have necrotizing fascists on your ballsack!

32
Commentr/WTFMay 17, 2012

This was hanging in our house when we moved in. Nine months later, its still there in all it's glory

Replying to tooshaytooshay · It's because Mel is, along being a belligerent, abusive drunk like Baldwin, also a racist bigot.

An antisemite in a town run by Jews. I wonder why he doesn't get any parts anymore...

23
Commentr/WTFDec 5, 2012

I see your frozen lock and your North Dakota winter and raise you a snow storm 33 miles above the arctic circle. (...plus kitty.)

Replying to Engineer3227 · 33 miles above the surface of the Earth is NOT space. Even 33 miles above the tip of Mount Everest doesn't put you into space.

Listen to this man, he's an engineer! You'd have to at least go ~220 miles above the surface to maintain orbit. The Kármán Line is 62 miles above the surface, which is considered the beginning of space. NASA seems to th

21