Comment · Thu, September 5, 2013

Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2h apart.

What they were answering

ADrugUser · 2 points

According to /u/MisterYouAreSoDumb, HHMA and HMMA are not neurotoxic and don't even pass the BBB, but HHMA is hepatotoxic.

(From http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/c763r0d)

EDIT: Argh. Sorry about the multiple re-edits. This stuff is too complex for me to fully understand.

u/MisterYouAreSoDumb

The initial dose inhibits CYP2D6, which causes more to be metabolized to MDA. That means that of course they will find less of the N-methylated metabolites than a linear dose accumulation, as it has already been N-demethylated by the secondary pathway, CYP3A4. This is the whole non-linear metabolism that I speak about in my theory.

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Comment · Thu, September 5, 2013 · 3 pts
Re-dosing is worse for you, because the N-demethylated metabolites are much more damaging than their N-methylated counterparts. Since MDMA has non-linear pharmacodynamics, the whole re-dosing issue is complicated. The in

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