Comment · Thu, April 18, 2013

Role of the 5-HT2c receptor in psychedelics.

Original post in this thread

frink99887 · 19 points

I'm aware that both the 5-HT2a and 2c receptors are both involved in psychedelics, but everything I've read thus far says that only 2a agonism is required for a psychedelic experience. My concern is that I'm a fan of tramadol which, along with it's metabolite o-desmethyltramadol, is a 5-HT2c antagonist.

My question is how much does the 2c receptor affect psychedelics, and if it plays a big part, would taking tramadol tonight be a bad call if I'm planning on tripping tomorrow?

(I'm x-posting to /r/askdrugs but I figured I would get a more informed response here.)

What they were answering

[deleted] · 3 points

[deleted]

u/MisterYouAreSoDumb

Probably because you are making blanket statements about substances that we know a hell of a lot about. Just because you don't understand the specifics of the mechanisms, does not mean nobody does.

There are literally thousands of research papers regarding the two substances you mentioned. Many of the pharmacodynamics have been proven in vitro and in vivo. Does that mean we know everything? Hell no. However, we know a hell of a lot more than your post alludes to.

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