Comment · Thu, March 28, 2013 · Ceretropic
[Personal Experience] Sunifiram: First Try; Initial Thoughts
Original post in this thread
[deleted] · 35 points
I ordered 1 gram of Sunifiram from NSN, and now that I've tried it, I have just ordered two more grams... Here is my first report:
As background, I am forty-seven years old, female, who is experimenting with different nootropic stacks in order to keep Alzheimer's at bay. My mother had early onset Alzheimer's in her early fifties and she died much too young. I refuse to follow that path. I had my genetic profile done via 23 and Me, and found that I do have an extremely high risk of developing early onset Alzheimer's. I eat a whole foods "ancestral" diet, and am in great shape for my age. For exercise I run, do a kettlebell routine twice a week, and am on a roller derby team. I will post my full stack in the sub here in another week or so.
Also, I respond extremely well to racetams.
I took five mg - measured on a good scale - after my morning run. I thought about taking it prior to exercise, but since I run outside, I didn't want to risk the chance of stomach upset or worse.
I didn't mix the powder with anything - I took it sublingually, and after a minute, drank a glass of water. About ten minutes later, I thought I felt a mood lifting, a slight widening of perspective. It is…
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Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
I hate to be the one to bring it up, but be wary of the placebo effect. Not that I would not be delighted to find that sunifiram provided novel effects. However, given the studies and the anecdotes I have seen, the effects should be very similar to piracetam, just at much lower doses.
http://www.scribd.com/doc/112186880/Full-Text
>The DM235-induced antiamnesic effect was of the same intensity as that exerted by the well-known nootropicdrugs piracetam (30 mg kg
–1
i.p.), aniracetam (100 mgkg
–1
p.o.) or rolipram (30 mg kg
–1
p.o.) (Fig.2A and B).Lower doses of DM235 (0.0001 mg kg
–1
i.p.), piracetam(10 mg kg
–1
i.p.) aniracetam (50 mg kg
–1
p.o.) or rolipram(10 mg kg
–1
p.o.) (Fig.2A and B) were devoid of anyameliorative effect on scopolamine-induced amnesia. At0.1 mg kg
–1
i.p., the entrance latency value of the DM235-treated group in the retention session was comparable tothat produced by control mice.
That does not mean that it is devoid of other novel effects, though. Keep us updated as you continue trialing it.