Comment · Thu, March 7, 2013 · Ceretropic
Questions about acetylcholine receptor antagonism and various interactions
Original post in this thread
amirrorbehind · 1 points
I take Tramadol and I'm trying to understand what exactly it's doing to my body and what I might stack with it to alleviate anything unwanted.
* What are, in general, the consequences of acetylcholine receptor antagonism? By preventing ACh from binding from its receptors (nicotinic [alpha-7] and muscarinic [m1, m3]) is ACh actually not doing its job? Or doing its job less?
* Should I be supplementing choline in this situation? It seems like antagonism would prevent choline (and then ACh) from performing its functions, so perhaps choline supplementation would be a waste?
* In this situation, what would an acetylcholinesterase inhibitor do? I'm looking at Huperzine-A.
I'm looking at the table just under here[1] and I'm wondering, for M1 and M3, by antagonising these receptors, am I preventing those actions from occuring ? Or at least somewhat?
[1] http://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor#Difference_in_G_proteins
Thanks for any and every response :).
What they were answering
[deleted] · 2 points
[deleted]
u/MisterYouAreSoDumb · Ceretropic
I cannot find anything on how a racetam might affect Tramadol's opioid agonism.
It shouldn't affect the opioid agonism. However, Tramadol is only a weak opioid agonist. Most of it's effects arise from other systems like serotonin and norepiniephrine. Ach plays a role as well, so racetams may affect that.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573343/
In conclusion, tramadol inhibits catecholamine secretion at least partly by inhibiting nicotinic AChR functions at clinically relevant concentrations in a manner independent of opioid receptors. The inhibitory effects of tramadol on nicotinic AChR functions might be one of the antinociceptive mechanisms exerted by tramadol.