Comment · Tue, March 5, 2013
MDMA and Liver Enzymes, Part One OTC
Original post in this thread
Synzael · 32 points
In this post i will focus on my study on liver enzyme inhibitors and their effects on MDMA. Many of you probably already know about how CYP3A4 metabolizes MDMA to MDA(which is transformed into the neurotoxic aMD). For my cake day I want want to look at 3 over the counter inhibitors of them and how they affect your roll.
First we have white grapefruit juice, a well known potentiator of illicit substances which inhibits CYP1A2 and CYP3A4. if you take it before you drop you will end up having less MDMA metabolize to MDA and your roll will last about 10% longer. It is also a good way to restore those electrolytes while your rolling.
Second, we have Quercetin. A popular antioxidant combined with MDMA, it is a inhibitor of CYP2C9 and CYP3A4. it is also known to induce CYP3A4 so dont take it too early before you roll or you risk counteracting your efforts.
Third, We have Cimetidine a H2 receptor antagonist like Pepcid AC except sold as "Tagamet". It affects much more liver enzymes than the standard Famotidine and greatly lowers your stomach acid contents and thus potentiates MDMA heavily. It inhibits CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. This can alter your roll but Ci…
What they were answering
Synzael · 2 points
I mean for preloading xD but you are correct in that most people don't postload for very long before preloading again for their redose :(
u/MisterYouAreSoDumb
Preloading should not be an issue. If you need to preload, you are doing it too much. I would suggest that person take a step back and think about why they need to preload, before taking more MDMA.