Comment · Thu, December 27, 2012
Re-dosing MDMA.
Original post in this thread
[deleted] · 6 points
I'm heading out to a gig this Thursday and am looking for some advice on re-dosing MDMA. The show runs from 10pm-6am and ideally I'd like to be peaking for at least the latter half of the night (1am-5amish).
I've used MDMA enough times to be comfortable with its effects but haven't tried to prolong the effects past a large initial dose (2 pills) and a small subsequent booster (1 more). This formula tends to last around 3 hours)
My plan is to take 2 pills at 12, take another 2 at 1.30 and a final one around 4. Is this a reasonable plan? or am I just going to cook myself out? It should be noted though that these are Australian pills so double dropping is a standard dose and tends to last around two hours. Yes, it's shit I know...
Any help would be much appreciated!
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
Re-dosing significantly increases the risk of neurotoxicity. This is due to many factors, including the initial dose inhibiting CYP2D6. This causes a change in the way any subsequent doses are metabolized. There is also evidence that the binding mechanism that instigates MDMA's primary effects becomes very desensitized after about 1.5-2 hours of the roll. This means that any re-dose after that time will be significantly less effective, while at the same time being over double the chance for neurotoxcity as the first dose. As someone that values his brain, I do not find that trade off acceptable. I will NEVER re-dose past the 1.5 hour mark with more MDMA. There is simply no point. I would suggest THC or a dissociative like ketamine or NOS to bring back the roll feelings. Borax mentioned amphetamine, and this would be better than taking more MDMA. However, it's going to drastically raise your body temps at the exact time your antioxidants systems are being overwhelmed. It will lead to more risk of damage, and your comedown will be worse. If the choice is between more MDMA and amp, I would choose the Amp, though. If you are going for 250mg, I would take 150mg initial dose followed by a 100mg re-dose at 1.5 hours after drop. If you are looking to dance, I would add amphetamine in there at the beginning. Be careful though, your pills may already have Amp in them.
Take grapefruit juice. It will inhibit CYP3A4 metabolism, which will extend your roll and make it stronger. I would suggest slightly lowering your dose if you do. My MDMA regimen last 6 hours, and has zero comedown. I don't go chasing the feeling after that. I am content to call it a night and get a good nights sleep for the afterglow the next day. I would suggest that as well, but it's up to you.